Pericentromeric demethylation and chromosomal instability induced by chemicals
نویسندگان
چکیده
منابع مشابه
Chromosomal DNA demethylation specified by protein binding.
In the present study, we utilize the well-characterized Escherichia coli lac repressor/operator system to demonstrate that protein binding can lead to demethylation at the binding sites in the chromosome. Similar to the findings using the episome, we found that the presence of LacI in the cells can lead to demethylation of methylated lacO in the chromosome and the LacI inhibitor, isopropyl-beta...
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DNA hypomethylation is a common trait of colorectal cancer. Studies in tumor cell lines and animal models indicate that genome-wide demethylation may cause genetic instability and hence facilitate or accelerate tumor progression. Recent studies have shown that DNA hypomethylation precedes genomic damage in human gastrointestinal cancer, but the nature of this damage has not been clearly establi...
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The iodinated radiopaques are widely used in radiologicals procedures for their higher quality and for better pathological diagnosis. Since they are numerous and can lead to cellular toxicity and/or genotoxicity, this study was carried out to investigate the efficacy of two routine compounds, that is, urographin 76% and telbrix 38. For this purpose, the metaphasic chromosomes of 30 patients un...
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Genetic instability is a defining feature of human cancer. The main type of genetic instability, chromosomal instability (CIN), enhances the rate of gross chromosomal changes during cell division. CIN is brought about by mutations of CIN genes, i.e. genes that are involved in maintaining the genomic integrity of the cell. A major question in cancer genetics is whether genetic instability is a c...
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The link between aneuploidy and cancer has been recognized over a century ago (1). Abnormalities in chromosome copy numbers arise from persistent errors in chromosome segregation during cell division, a process known as chromosomal instability (CIN) (2). CIN is a principal contributor to genetic heterogeneity in cancer (3) and is an important determinant of clinical prognosis and therapeutic re...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2007
ISSN: 1471-2407
DOI: 10.1186/1471-2407-7-s1-a24